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Identification of Alcohol Biomarker Signatures

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Mar 23, 2005
Applications Due:

Jun 15, 2005

total funding: $2,000,000
max award: none
min award: none
cost sharing, matching: No
number of awards: 6
type of funding: Grant

This Request for Applications (RFA) fosters the utilization of genomic, proteomic, and metabolomic technologies for the development of diagnostic biomarker signatures for alcohol consumption and alcohol-induced tissue injury. Specifically, the research program is aimed at identifying signatures of acute and chronic alcohol consumption for diagnosing high-risk drinking, detecting relapse to drinking, disclosing recent drinking in high risk situations such as pregnancy, as well as signatures for alcohol-induced early tissue damage including brain damage, alcoholic liver disease (ALD), pancreatitis, immune disorders, cancer, cardiomyopathy and other alcohol-induced diseases. Recent advances in high-throughput technologies in genomics, proteomics, and metabolomics, in combination with robust bioinformatics enable researchers to rapidly survey thousands of differentially expressed genes, proteins, or metabolites simultaneously, thus employing an integrative!
approach to identify unique biomarker signatures. These state-of-the-art technologies provide a great opportunity to discover a new generation of biomarkers. These signatures could lead to the identification of potential targets for medication development and for evaluating the efficacy of lead compounds in clinical trials. We encourage collaborations from disparate scientific areas and disciplines, including those not traditionally supported by NIAAA combining unique and complementary expertise, techniques, model systems and tissues. It is essential, however, that the proposed activities be within the mission of NIAAA.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Alcohol Research Programs

More Information:


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